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Thursday, May 7, 2020 | History

3 edition of Pharmacophore perception, development, and use in drug design found in the catalog.

Pharmacophore perception, development, and use in drug design

Pharmacophore perception, development, and use in drug design

  • 304 Want to read
  • 31 Currently reading

Published by International University Line in LaJolla, CA .
Written in English

    Subjects:
  • Drugs -- Structure-activity relationships.,
  • Drugs -- Design.

  • Edition Notes

    Includes bibliographical references and index.

    Statementedited by Osman F. Güner.
    SeriesIUL biotechnology series
    ContributionsGüner, Osman F, 1956-
    Classifications
    LC ClassificationsRM301.42
    The Physical Object
    Paginationxiii, 537 p., xx p. of col. plates :
    Number of Pages537
    ID Numbers
    Open LibraryOL22138638M
    ISBN 100963681761

      Throughout the book, industrial and academic drug discovery strategies are addressed, with contributors coming from both areas, enabling an informed decision on when and which data mining tools to use for one's own drug discovery project. Güner, O. F. and Henry, D. R. "Metrics for Analyzing Hit Lists and Pharmacophores” in Pharmacophore Perception, Development, and Use for Drug Design, Güner, O. F.

    Pharmacophore perception, development, and use in drug design. LaJolla, CA: International University Line. ISBN Langer T, Hoffmann RD (). Pharmacophores and pharmacophore searches. Weinheim: WILEY-VCH. ISBN   Introduction. Fully automated methods of pharmacophore model design can help facilitate the process of modern computer based drug discovery (Chen et al., ; Wallach & Lilien, ).Computers gain credibility in the field of computational biology and drug design, as new and more efficient algorithms and pipelines are established (Donsky & Wolfson, ; Loukatou et al., ; Cited by: 6.

      In the absence of three-dimensional (3D) structures of potential drug targets, ligand-based drug design is one of the popular approaches for drug discovery and lead optimization. 3D structure-activity relationships (3D QSAR) and pharmacophore modeling are the most important and widely used tools in ligand-based drug design that can provide crucial insights into the nature of the interactions Cited by:   Pharmacophore in Drug Design and Discovery • A pharmacophore model is a geometrical description of the chemical functionalities required of a ligand to interact with the receptor. modern medicinal chemistry is to reduce the overall cost - discovery and development of a new drug, by identifying the most promising candidates to focus on the.


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Pharmacophore perception, development, and use in drug design Download PDF EPUB FB2

In the early s, Paul Ehrlich first defined pharmacophores as molecule frameworks that carry the essential features responsible for a drug's biological activity, and the modern definition is little changed.

The 27 studies here begin by tracing the evolution of the concept in pharmaceutical research, then cover analog-based and receptor-based varieties, new algorithms, and the future of.

Pharmacophore Perception, Development, and Use in Drug Design (Iul Biotechnology Series, 2) Hardcover – February 1, by Osman F. Guner (Editor) out of 5 stars 1 rating. See all formats and editions Hide and use in drug design book formats and editions.

Price New from 4/5(1). The book entitiled Pharmacophore P erception, Development, and Use in Drug Design, which has been just released [1], is the first monograph ded icated to the to pic of the pharmacophor e.

It isAuthor: Shu-Kun Lin. The book entitiled Pharmacophore Perception, Development, and Use in Drug Design, which has been just released [1], is the first monograph dedicated to the topic of the pharmacophore.

It is authored by 56 experts [2] in the fields of computational chemistry and chemo- and bioinformatics. PHARMACOPHORE PERCEPTION, DEVELOPMENT, AND USE IN DRUG DESIGN edited by OSMAN F. GÜNER Preface: Perceiving a pharmacophore is the most important first step towards understanding the interaction between a receptor and a ligand.

In the early s, Paul Ehrlich offered the. The book entitiled Pharmacophore Perception, Development, and Use in Drug Design, which has been just released [], is the first monograph dedicated to the topic of the is authored by 56 experts [] in the fields of computational chemistry and chemo- and first chapter stes the tone for the volume by and use in drug design book a very interesting account of the evolution of the Cited by: Yet, quite surprisingly, this book is the first book that has the word “pharmacophore” in its title.

We therefore wanted to be very comprehensive in this first volume, covering all aspects of pharmacophore perception, development, and use in drug design. see larger photo. Look inside this book. Abstract: Q uoting Robert S. Pearlman, Coulter Sublett Regents Chair in Pharmacy in the University of Texas at Austin 'Pharmacophore perception and the use of perceived pharmacophores comprise the fundamental essence of all CADD methods.' Quoting the Editor's first sentence in the Preface of the book 'Perceiving a pharmacophore is the most important.

: pharmacophore. Skip to main content. Try Prime All Go Search EN Hello, Sign in Account & Lists Sign in Account & Lists Orders Try Prime Cart. Today's Deals Your Gift Cards Help.

Get this from a library. Pharmacophore perception, development, and use in drug design. [Osman F Güner;]. Development and Use in Drug Design Pharmacophore Perception reviews BOOKS Billmeyer and Saltzman's Principles of Colour Technology 21 July Organic Synthesis on Solid Phase 14 July Experimental Organic Chemistry 7 July Rare Earth 30 June Tower of Babel 16 June archive Osman F.

Güner $ The book entitiled Pharmacophore Perception, Development, and Use in Drug Design, which has been just released [1], is the first monograph dedicated to the topic of the pharmacophore.[ ] View Full-TextCited by: The book entitiled Pharmacophore Perception, Development, and Use in Drug Design, which has been just released [1], is the first monograph dedicated to the topic of the pharmacophore.

It is authored by 56 experts [2] in the fields of computational chemistry and chemoand bioinformatics. The first chapter stes the tone for the volume by giving a very interesting account of the evolution of the.

Pharmacophore approaches have become one of the major tools in drug discovery after the past century's development. Various ligand-based and structure-based methods have been developed for improved pharmacophore modeling and have been successfully and extensively applied in virtual screening, de novo design and lead optimization.

Despite these successes, pharmacophore Cited by: This chapter discusses quantitative structure–activity relationships (QSAR) and pharmacophore mapping strategies in novel anticancer drug discovery.

The overall objective of any QSAR study is to identify parameters that give a statistically significant correlation with the observed biological activity of a Author: James J. Kaminski. Pharmacophore Perception, Development, and Use in Drug Design. La Jolla: Internat’l University Line.

McGregor MJ, Muskal SM. Pharmacophore fingerprinting. Application to QSAR and focused library design. J Chem Inf Comput Sci. ;39(3)– McGregor MJ, Muskal SM. Pharmacophore fingerprinting. Application to primary. Drug design, often referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target.

The drug is most commonly an organic small molecule that activates or inhibits the function of a biomolecule such as a protein, which in turn results in a therapeutic benefit to the patient.

[PDF] Pharmacophore Perception, Development, and Use in Drug Design (Iul Biotechnology Series, 2). Gund P () Evolution of the pharmacophore concept in pharmaceutical research.

In: Güner OF (ed) Pharmacophore perception, development, and use in drug design. International University Line, La Jolla, CA, p 5 Google ScholarCited by: 1.

Gu¨ner, O.F. Pharmacophore Perception Development and Use in Drug Design, International University Line Langer, T. and Hoffmann, R.D. Pharmacophores and Pharmacophore Searches,Wiley VCH.

Kirchmair, J. et al. () Comparative analysis of protein-bound ligand conformations with respect to catalyst’s conformational space sub. With computer-aided drug design established as an integral part of the lead discovery and optimization process, pharmacophores have become a focal point for conceptualizing and understanding.

Download Pharmacophore Perception Development and Use in Drug Design (Iul Biotechnology Series.The book entitiled Pharmacophore Perception, Development, and Use in Drug Design, which has been just released [1], is the first Expand.